Lack of effect of paracetamol on the pharmacokinetics of chloramphenicol.

Authors
Category Primary study
JournalBritish journal of clinical pharmacology
Year 1989
The effect of oral paracetamol (1 g) on the pharmacokinetics of oral chloramphenicol (500 mg) was examined in five adult male Zimbabwean patients with normal hepatic and renal function. No significant alteration of half-life, area under the concentration-time curve or peak concentration of chloramphenicol was observed. The previously reported, potentially serious interaction between chloramphenicol and paracetamol administered intravenously was not observed with the more commonly used oral preparations.
Epistemonikos ID: e24fefcc7ef491cc1fb4373cc885836b58d523e5
First added on: May 14, 2022