Long-term Investigation of Resveratrol on Fat Metabolism in Obese Men With Nonalcoholic Fatty Liver Disease

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2011
The purpose of this study is to investigate potential metabolic effects of resveratrol in obese healthy men with non-alcoholic fatty liver disease. The investigators hypothesize that resveratrol will: * decrease hepatic very-low-density-lipoprotein-triglyceride (VLDL-TG) secretion * decrease liver fat content * increase insulin sensitivity The investigators will look at changes in: * lipid turnover (VLDL-TG kinetics, palmitate kinetics, indirect calorimetry) * liver fat content (MR liver spectroscopy) * insulin sensitivity (glucose kinetics during hyperinsulinaemic euglycaemic clamp) * body composition (DXA and MRI) * lipase activity and fat cell size (fat biopsy from abdominal and femoral adipose tissue)
Epistemonikos ID: e0ecf31d0f70ceb2f88676d05a6e290139389ea8
First added on: May 10, 2024