The effect of probiotic administration on severity of the menopausal symptoms and mental health

INTERVENTION: Intervention 1: Intervention group: Probiotic supplement will be prescribed in the form of Oral Capsule 200 mg, Once a day for 6 weeks. Including Lactobacillus plantarum, Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus bulgaricus, Bifidobacterium infantis, Bifidobacterium longum, Bifidobacterium breve and Streptococcus thermophilus.This drug Will be Producted by Hamadan University of Medical Sciences. Intervention 2: Control group: placebo will be prescribed in the form of Oral Capsule contain ?of Starch 200 mg Once a day for 6 weeks. The placebo is made in Hamadan University of Medical Sciences. CONDITION: N95.1 Severity of the Menopausal Symptoms and Mental health. ; Menopausal and female climacteric states PRIMARY OUTCOME: Anxiety. Timepoint: Before the intervention, 3 and 6 weeks after the intervention. Method of measurement: Questionnaire DASS‐21. Depression. Timepoint: Before the intervention, 3 and 6 weeks after the intervention. Method of measurement: Questionnaire DASS‐21. Severity of menopause symptoms. Timepoint: Before the intervention, 3 and 6 weeks after the intervention. Method of measurement: MRS scale. Stress. Timepoint: Before the intervention, 3 and 6 weeks after the intervention. Method of measurement: Questionnaire DASS‐21. INCLUSION CRITERIA: age between 45‐55 not using cigarette or alcohol not having physical or mental diseases not using of relaxation techniques not using of hormonal or herbal therapies