Transcutaneous auricular vagus nerve stimulation for preventing agitation and emergence delirium after tonsillectomy and adenoidectomy in children: a multicenter, double-blind, randomized controlled trial

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Active stimulation group:Percutaneous electrical stimulation of the left auricle;The sham stimulation group:Simulate stimulation of the left auricular cone; CONDITION: A series of negative behavioral symptoms that children exhibit during the early stage of general anesthesia recovery, such as postoperative agitation (Emergence Agitation, EA) and emergence delirium (Emergence Delirium, ED), manifest as crying, struggling, and disorientation, etc. PRIMARY OUTCOME: The incidence rate of delirium during the recovery period (ED); SECONDARY OUTCOME: adverse event;Quality of Children's Rehabilitation;The incidence of postoperative pain;recovery time; INCLUSION CRITERIA: 1. Visited the Zhejiang Provincial Hospital of Traditional Chinese Medicine , Changzhi Maternal and Child Health Hospital, and Heping Hospital Affiliated to Changzhi Medical College. Diagnosed with hypertrophy of the tonsils and/or adenoids. Planned to undergo tonsil and/or adenoid removal surgery under general anesthesia with sevoflurane inhalation. 2. American Society of Anesthesiologists classification (ASA) level 1‐2. 3. Be able to understand the research process and the use of various assessment scales, and be able to communicate effectively with the researchers. 4. Aged 3 to 8 years old;
Epistemonikos ID: df8d862a867f97612a95b9890493296f6956d877
First added on: Oct 08, 2026