Efficacy of pretreatment by medicines on post endodontic pain

INTERVENTION: Celecoxib as capsule 200mg, per oral one dose 2 houres before starting the treatment Gelofena as capsule 400 mg, oral, one dose 2 houres before starting the treatment Intervention 1: Gelofena as capsule 400 mg, oral, one dose 2 houres before starting the treatment. Intervention 2: placebo as capsule, oral one dose 2 houres before starting the treatment. Intervention 3: Celecoxib as capsule 200mg, per oral one dose 2 houres before starting the treatment. Placebo placebo as capsule, oral one dose 2 houres before starting the treatment Treatment ‐ Drugs CONDITION: Disorder of teeth and supporting structures, unspecified Endodontic pain. ; Disorder of teeth and supporting structures, unspecified PRIMARY OUTCOME: Pain. Timepoint: 4, 8, 12, 24 and 48 hours after intervention. Method of measurement: VAS scale. INCLUSION CRITERIA: INCLUSION CRITERIA: age between 18 to 65; and having vital premolars of mandible or maxilla without any pre apical lesion Exclusion criteria: pregnancy; allergy to sulfonamide and NSAIDs; history of asthma related to nasal polyp; history of chronic using of analgesics; alcohol using; uncontrollable high blood pressure; diabetes mellitus; systemic disease and not using analgesic medicine 12 hours before study