Randomized clinical trial about the period of antimicrobial prophylaxis administration in total gastrectomy for gastric cancer.

INTERVENTION: Ampicillin‐sulbactam is administered after the induction of anesthesia, and the patients received an additional dose if the operation was prolonged beyond 3 hour, and Ampicillin‐sulbactam was administered again twice daily for 3 consecutive days after the operation Ampicillin‐sulbactam is administered after the induction of anesthesia, and the patients received an additional dose if the operation was prolonged beyond 3 hour, and Ampicillin‐sulbactam was administered at 6 hour and 18hour at end of the operation. CONDITION: Gastric cancer patients undergoing elective total gastrectomy PRIMARY OUTCOME: The primary outcome is to show that a 24 hours antibiotic administration of the end of the operation was not inferior to the 3 days antibiotic administration of the postoperative period. SECONDARY OUTCOME: The secondary outcome is to investigate the incidence of remote infection in each group. INCLUSION CRITERIA: Gastric cancer patients undergoing elective total gastrectomy (up to D2 lymph node resection by Japanese classification and R0 resection by UICC TNM Classification).