Multimodality magnetic resonance imaging study of Huangjingjiannao prescription in the treatment of vascular mild cognitive impairment

Authors
Category Primary study
Registry of TrialsITMCTR
Year 2022
INTERVENTION: Test group:give Huangjingjiannao prescription for 8 weeks;Healthy control group:Non‐intervention;Control group:give Donepazil tablets 0.5mg/ days for 8 weeks; CONDITION: F06.700 Vascular Mild Cognitive Impairment PRIMARY OUTCOME: Symptom score scale of Chinese medicine;MoCA;Neuropsychological scale test;ADL;HAMD‐17;MMSE; SECONDARY OUTCOME: Blood sugar;TG;low density lipoprotein(LDL);D‐dimer;high density lipoprotein(HDL);prothrombin time(PT);Blood calcium;prothrombin time(PT);Fibrinogen(FIB);activated partial thromboplastin time(APTT);HCY;TC; INCLUSION CRITERIA: ? Between 40 and 75 years old; ? Primary school degree or above or the same educational level, with a certain degree of Education: ? have impairment symptoms in any cognitive field; ? The overall cognitive function was basically normal, and the MMSE score was less than 24; ? The ability of daily living was basically normal, and the score of ADL ranged from 20 to 26; ? Not in accordance with the diagnosis of dementia, clinical dementia rating scale (CDR) =0.5; ? TCM syndrome belongs to kidney deficiency and blood stasis syndrome, TCM syndrome score = 7 points; ? Brain CT or MRI has the imaging manifestations of ischemic leukoencephalopathy. Cranial CT: localized in paraventricular area or bilateral patchy or diffuse low‐density area extending to the center of semi oval (CT value is 5‐10hu lower than the normal value), the boundary is fuzzy, and the enhanced scan is not enhanced. Cranial MRI showed T2 high signal and T1 signal or low signal changes in paraventricular
Epistemonikos ID: dd9522d1a814c5c80bc2849483e37b8f66ac51cd
First added on: Aug 26, 2024