Aged garlic extract for uncontrolled hypertension: a dose-response trial

INTERVENTION: Active groups: Aged garlic extract (AGE, Kyolic) orally daily for 12 weeks Group 1: 4 capsules containing 960 mg AGE, 2.4 mg S‐AllylCysteine (SAC) Group 2: 2 capsules containing 480 mg AGE, 1.2 mg SAC Group 3: 1 capsule containing 240 mg AGE, 0.6 mg SAC CONDITION: treated uncontrolled hypertension PRIMARY OUTCOME: Blood pressure, mean of three serial measures, with Omron HEM‐907 sphyngomanometer by research assistant SECONDARY OUTCOME: Acceptability by questionnaire using 5‐point likert scales INCLUSION CRITERIA: Blood pressure > 140 mm Hg systolic under trial conditions; on established plan of BP medication (one or more classes) for at least 2 months