Equivalence trial of tribendimidine versus albendazole against hookworm infections in Ivory Coast

INTERVENTION: Intervention group: single oral dose of 400 mg tribendimidine Control group: single oral dose of 400 mg albendazole CONDITION: Hookworm infection (Necator americanus and Ancylostoma duodenale) ; Infections and Infestations ; Hookworm infection PRIMARY OUTCOME: 1. Cure rate at 21 day post‐administration; 2. Egg reduction rate at 21 day post‐administration; 3. Observed acute adverse events within 1‐3 hours and solicited adverse events within 24 hours SECONDARY OUTCOME: Rate of perceived illness episodes throughout the 6 months follow‐up period with 1 week recall period INCLUSION CRITERIA: Hookworm egg positive adult males (16‐45 years) recruited at community survey in the region of Agboville (south Ivory Coast ) with written informed consent