The effects of an Oroxylum indicum extract (Sabroxy) on cognitive function in adults with mild cognitive impairment

INTERVENTION: Condition 1: Placebo capsules (1 capsule taken orally, twice daily after food at breakfast and dinner times for 12 weeks) Condition 2: Oroxylum indicum extract (Sabroxy) (1 capsule taken orally, twice daily after food at breakfast and dinner times, delivering 1000mg a day, for 12 weeks) Adherence to capsule intake will be monitored through capsule return and count. CONDITION: Alternative and Complementary Medicine ‐ Herbal remedies Mild cognitive impairment; ; Mild cognitive impairment Neurological ‐ Other neurological disorders PRIMARY OUTCOME: Change in cognitive performance as measured by the Computerised Mental Performance Assessment System (COMPASS)[Weeks 0 and 12] SECONDARY OUTCOME: Change in blood concentration of brain‐derived neurotrophic factor (BDNF)[Weeks 0 and 12] Change in cognitive performance as measured by the Montreal Cognitive Assessment (MoCA)[Weeks 0 and 12] Change in cognitive skills as measured by the Cognitive Failures Questionnaire (CFQ)[Weeks 0, 4, 8, and 12] Change in quality of life as measured by the CASP‐19[Weeks 0, 4, 8, and 12] INCLUSION CRITERIA: 1. Adults (male and female) between 60 and 85 2. Residing in independent living accommodation 3. Subjective reports of memory or cognitive impairment as measured by answering ‘yes’ to any of the following questions: (1) Do you feel your memory and thinking is getting worse? or (2) Are you concerned about your decline in memory and thinking? 4. A score between the 10th and 40th percentile for age, education, and gender on the Telephone Interview for Cognitive Status (TICS‐M) 5. Non‐smoker 6. BMI between 18 and 35 kg/m2 7. No plan to commence new treatments over the study period 8. Understand, willing and able to comply with all study procedures 9. Willing to provide a personally signed and dated informed consent form detailing all pertinent aspects of the trial.