Repeated virtual reality sessions in fibromyalgia: a prospective observational study

Aims: Fibromyalgia (FM) is a chronic pain syndrome with limited effective treatments. This study evaluated virtual reality (VR) as an adjunct therapy. Methods: Participants used the HealthyMind program delivered via a Pico G2 4K Enterprise headset in eight supervised, seated 20-minute sessions over four weeks, featuring nature relaxation, guided imagery, and meditation. Primary outcome was Pain Numerical Rating Scale (NRS) at one month (M1); secondary outcomes included PCS, PSEQ, and HADS. Results: Fifty participants completed baseline and M1 assessments. Pain significantly decreased from 6.8 ± 1.5 to 5.8 ± 1.9 (−14.8%, p < 0.001; effect size = 0.56). Significant improvements were observed in catastrophizing, self-efficacy, anxiety, and depression. Conclusion: Repeated HealthyMind VR use was associated with reduced pain and improved psychological outcomes in FM patients. Clinical trial registration: www.clinicaltrials.gov identifier is (NCT05567861).