Vitamin B Complex and Diabetic Nephropathy in Type 1 Diabetes

This trial included 80 vitamin B12‐deficient T1DM patients with nephropathy, despite oral angiotensin‐converting enzyme inhibitors . Enrolled patients aged 12‐18 years with at least 5 years disease duration and HbA1c ≤8.5%. Patients were randomly assigned into two groups; intervention group who received vitamin B complex once daily orally . The other group did not receive any supplementation and served as a control group. Both groups were followed‐up for 12 weeks with assessment of plasma homocysteine, HbA1c, cystatin C and UAE.