The bone effects of pioglitazone

INTERVENTION: Pioglitazone 30mg per oral daily for 12 months CONDITION: Osteoporosis Type 2 diabetes mellitus PRIMARY OUTCOME: Change in lumbar spine bone density, measured by dual energy xray absorptiometry SECONDARY OUTCOME: Change in total hip bone density, measured by dual energy xray absorptiometry Chnage in biochemical markers of bone formation, assayed in serum INCLUSION CRITERIA: ‐ Type 2 diabetes mellitus (T2DM), as defined by fasting blood glucose > 7mmol/L and/or serum glucose > 11mmol/L 2h after ingesting 75g oral glucose. ‐ impaired glucose tolerance, as defined by fasting blood glucose < 6‐7 mmol/L and/or serum glucose 7.8‐11mmol/L 2h after ingesting 75g oral glucose