A randomized controlled clinical trial of fecal bacteria transplantation for multiple sclerosis

INTERVENTION: Group 1:fecal microbiota transplantation;Group 2:conventional therapy; CONDITION: Multiple sclerosis PRIMARY OUTCOME: The EDSS increased by 1 points or more in 60 weeks and continued for 12 weeks.; SECONDARY OUTCOME: The progression of upper limb functional disability increased by 20% at 60 weeks and continued for 12 weeks.;the ratio of 25 step walking speed of the subjects decreased by 20% and lasted for 12 weeks in 60 week.;Recurrence times;Annual recurrence rate;new lesion in MRI; INCLUSION CRITERIA: (1) Aged 18‐55 years; (2) MS is diagnosed according to the diagnostic criteria of McDonald (Revised Edition 2010); (3) the course of the disease was 2‐10 years; (4) the baseline of the EDSS score was 2‐5 points before the treatment; (5) relapse remission has recurred in the past 12 months. (6) secondary progressive type had recurrence within the past 12 months, or the EDSS score increased by 1 points. (7) there were recurrences in primary progression or GAD enhancement in head MRI.