A Clinical valuation of efficacy and safety of Unani Formulation in Warm Tajawif al-Anf Muzmin (Chronic Sinusiti)

INTERVENTION: Intervention1: Polyherbal Unani Formulation: Dosage Form: Decoction Using Raw Drugs Dose: 45gm Daily One Time Duration: 42 days Route of Administration: Oral Composition of Formulation: 1‐ Aslussoos (Glycyrrhiza glabra Linn.) 4.5 gm 2‐ Badiyaan (Foeniculum vulgarae Mill.) 4.5 gm 3‐ Banafsha (Viola odorata Linn.) 4.5 gm 4‐ Parsiyaoshan (Adiantum capillus‐veneris L.) 4.5 gm 5‐ Gaozaban (Borage officinalis Linn.) 4.5 gm 6‐ Maviz Munaqqa (Vitis vinifera Linn.) 10 gm 7‐ Nabat (Saccharum officinarum) 6 gm 8‐ Sapistan (Cordia latifolia Linn.) 6 gm Control Intervention1: levocetirizine: Dosage Form: Tablet Dose: 10 mg orally daily at bedtime Duration: 42 days CONDITION: Health Condition 1: J32‐ Chronic sinusitis Health Condition 2: F01‐F99‐ Mental, Behavioral and Neurodevelopmental disorders PRIMARY OUTCOME: Change in the Grading of X‐ray PNS (Thickened mucosal lining, opacity of sinus) ; Reduction in SNOT‐22 Score ; Reduction in VAS Score ; Reduction in Serum Level of Ig E ; Timepoint: 42 days SECONDARY OUTCOME: Systemic Safety AssessmentTimepoint: 42 days INCLUSION CRITERIA: 1. Duration of the disease >12 week. 2. Patient having at least two out of four cardinal symptoms (i.e., facial pain/pressure, hyposmia/anosmia, nasal obstruction, and nasal discharge for at least 12 consecutive weeks. 3. Patient having other symptoms rhinorrhea, nasal congestion, frontal headache, nasal itching, impaired sense of smell and frequent sneezing for more than 12 weeks. 4. Positive X‐ray PNS finding (Thickened mucosal lining, opacity of sinus).