A multi-center trial of combination therapy of hormonal therapy and Green Tea Extract (GTE) in stage C,D prostate cancer patients

INTERVENTION: Taking GTE tablet with hormonal therapy hormonal therapy alone CONDITION: Prostate cancer PRIMARY OUTCOME: Time to hormone refractory SECONDARY OUTCOME: Survival time (disease specific survival, overall survival) and adverse event INCLUSION CRITERIA: a) clinical stage C or D b) any age c) performance status 0‐3 d) both of beginning hormonal therapy (fresh cases)and under hormonal theprapy(under treatment cases)are included e) The PSA value of under treatment cases were normalized (less than 4 ng/ml) within 6 months after hormonal therapy, and the PSA value was stable. f) The PSA value before hormonal therapy was out of normal range. The measurement of PSA value is decided as Tandem‐R. The value with other measurement is converted into Tandem‐R. g) The treatment before hormonal therapy is not unrelated. h) Acquired informed consent with writing