COVID-19 induces Cytokine Storm and Dysfunctional Hemostasis.

Infection with SARS-CoV-2 leads to COVID-19 which can manifest in various ways from asymptomatic or mild disease to acute respiratory distress syndrome. The occurrence of dysregulated inflammatory responses in the form of a cytokine storm has been reported in patients with severe COVID-19. Infection can also lead to dysfunctional hemostasis reflected in d-dimer and fibrin degradation product levels. Components of the coagulation and inflammatory systems can interact with each other to result in a procoagulation or proinflammatory state. The interplay between coagulation and inflammation has been elucidated for various diseases. In this article, we will discuss the occurrence of cytokine storms and dysfunctional hemostasis induced in COVID-19.