Clinical Characteristics of Patients Coinfected with SARS-CoV-2 and Dengue

BACKGROUND: Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) producing COVID-19 disease and Dengue are both epidemic in Argentina. To date, most cases of both virus are from Buenos Aires city. Here we describe the clinical characteristics and follow up from a cohort  patients coinfected with dengue and SARS-CoV-2 in Buenos Aires. METHODS: We retrospectively identified patients from different Buenos Aires area hospitals who were admitted with confirmed infection with Dengue Virus and SARS-CoV-2. Clinical data were obtained through review of medical records. Patients had at least 3 weeks follow-up. RESULTS: Thirteen patients were identified. The median age was 37 years old, most of them didn't had any comorbidity, almost half were females, and all had febrile disease at presentation The median duration of fever was 7 days. Headache was a common symptom among coinfected subjects. A total of eight patients had respiratory symptoms. Five patients had pneumonia.  Three patients had rash that appear early in the course of the disease. Two of these patients had concomitant pneumonia and rash. Almost all patients had  Lymphopenia at presentation and thrombocytopenia in almost half of them. No patients required ICU or died during the follow up.     CONCLUSION: SARS-CoV2 and Dengue can produce coinfections in patients living in areas where both virus are epidemic. The outcome of these patients does not seem to be worse than having either SARS-Cov2 or Dengue alone. FUNDING STATEMENT: The authors stated that this article doesn´t have funding sources. DECLARATION OF INTERESTS: MES is a consultant to Basilea and the principal investigator for Argentina NIH grant UM1AI104681; all others have no interests to declare ETHICS APPROVAL STATEMENT: This study was approved by the Ethic Committee of Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina.