A multicenter prospective randomized controlled trial: comparison generic alginate Vs original alginate for symptoms controlled in the non-proton pump inhibitors responder GERD

INTERVENTION: Active Comparator Drug,Placebo Comparator Drug Generic alginate,Original alginate Previous standard‐dose proton pump inhibitor plus generic alginate (ONE GERD) 1 pack 4 times per day until 28 days,Previous standard‐dose proton pump inhibitor plus original alginate (Gaviscon dual suspension) 1 pack 4 times per day until 28 days CONDITION: GERD In patients with gastroesophageal reflu Xdisease, despite taking proton pump inhibitors But only 25.7% of symptoms could be controlled in 7 days and only 35.9% of GERD patients were found to have no heartburn symptoms over 28 days. Patients with GERD are chronic and affect their quality of life worse compared to normal people. which often affects sleep decreased vitality more pain in the body impaired sexual feelings and more anxiety. ; GERD PRIMARY OUTCOME: Number of response patients Day 7 and Day 28 Different of number of response patient SECONDARY OUTCOME: Symptom free days Day 28 Proportion,Adverse effect Day 28 Proportion INCLUSION CRITERIA: Thai patients aged 18 years and older with a diagnosis of gastroesophageal reflu Xdisease were treated with standard‐dose proton pump inhibitors for at least 4 weeks but did not respond to treatment. The criteria for GERD diagnosis are: Typical symptoms of GERD include heartburn and belching at least twice a week. with symptoms continually for 1 month. or with a score greater than or equal to 8 using a standardized questionnaire to help diagnose GERD. (Gastroesophageal Reflu XDisease Questionaire (GerdQ)). If the patient has warning symptoms (Alarm symptoms), they must do EGD before.