The effect of aldosterone inhibition on proteinuria in patients with progressive renal disease.

INTERVENTION: Pharmaceutical Form: CONDITION: Patients with chronic nephropathy and proteinuria over 0,5 g/24 hrs are to be given an inhibitor of aldosterone. Theory tells that aldosterone plays an active role in nephropathy and if that can be inhibited patients with chronic renal diseases may prolong their pre‐dialysis period of time. ; MedDRA version: 8.1 Level: SOC Classification code 10038359 Term: Renal and urinary disorders PRIMARY OUTCOME: Main Objective: To reduce protein excretion via urine in patients with chronic renal disease. Primary end point(s): Reduction in proteinuria after 8 weeks of treatment Secondary Objective: To evaluate if there is a tendency to reduce proteinuria via aldosterone inhibition and to prolong pre‐dialysis time for these patients. INCLUSION CRITERIA: Age more than 18 years. Acceptance from patients, gives of free will. Proteinuria > 0,5 g/24 hours Blood pressure is to be between 120‐130/70‐80 mmHg. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range