In-situ vs Ex-situ Liver Preservation

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2026
The goal of this Randomized Controlled Trial is to learn what machine preservation method is most clinically effective for liver transplantation (LTx) after donation after circulatory death (DCD). The main questions it aims to answer are: * What perfusion method has the lowest death censored biliary complication rate at 1-year post LT? * Are there differences in the Core Outcome Set of liver transplantation outcomes? * Are there any differences in utilization outcomes? * Are there any differences in cost effectiveness? * Are there any differences in patient quality of life? * Are there any differences in resource utilization? Researchers will compare preservation using in-situ abdominal normothermic regional perfusion (aNRP) to (dual) hypothermic oxygenated perfusion (DHOPE) or DHOPE followed by controlled oxygenated rewarming and normothermic machine perfusion (DHOPE-COR-NMP). Nothing will change from clinical practice for the liver recipients.
Epistemonikos ID: d4e4e01b07756de9501a3ec5425c5fac038a66a5
First added on: Oct 29, 2026