Proton pump inhibitors, oral and injectable, in preventing peptic ulcer re-bleeding

INTERVENTION: " intervention group: We will give pantoprazole tablet 40 mg every 12 hours for 72 hours and then will continue with same dose for 4 weeks "Control group: We will give IV pantoprazole 40 mg as stat dose and then 8 mgr per hours for 72 hours .we will continue pantoprazole tablet 40 mgr twice daily for 4 weeks. Intervention 1: " intervention group: We will give pantoprazole tablet 40 mg every 12 hours for 72 hours and then will continue with same dose for 4 weeks. Intervention 2: "Control group: We will give IV pantoprazole 40 mg as stat dose and then 8 mgr per hours for 72 hours .we will continue pantoprazole tablet 40 mgr twice daily for 4 weeks. Treatment ‐ Drugs CONDITION: gastroduodenal ulcer. ; Peptic ulcer, site unspecified Peptic ulcer, site unspecified PRIMARY OUTCOME: Endoscopic evidence of bleeding from gastric or duodenal ulcer. Timepoint: ?Before intervention, 72 hours an 4 weeks after intervention. Method of measurement: Endoscopy before intervention, check of blood pressureand hemoglobin 72 hours and 4 weeks after intervention. SECONDARY OUTCOME: Days of hospitalization. Timepoint: Upto 4 weeks after intervention. Method of measurement: Questionnaire. Need for surgery. Timepoint: Upto 4 weeks after intervention. Method of measurement: Questionnaire. The need for re‐endoscopy because of bleeding. Timepoint: Upto 4 weeks after intervention. Method of measurement: Questionnaire. The number of units of blood required. Timepoint: 8 weeks after intervention. Method of measurement: Questionnaire. INCLUSION CRITERIA: INCLUSION CRITERIA: Every person with upper gastrointestinal bleeding due to peptic ulcer, which is the new log endoscopic bleeding (bleeding ulcer in the jet, the vessel featured in the wound bed, the wound with mild persistent bleeding, and ulcers with adherent clots in bed ). Exclusion criteria: patients with upper GI bleeding with other causes, such as bleeding from esophageal or gastric varices or cancer and patients with clean base peptic ulcer without active bleeding.