Effect of statin for trans-catheter aortic valve implantation

INTERVENTION: Pravastatin group Standard group CONDITION: Aortic stenosis PRIMARY OUTCOME: MI; Cardiac/non cardiac death; stroke; Unplanned pacemaker implantation; unplanned open chestsurgery; Unplanned peripheral vascular intervention/surgical repair; Life thretening bleeding; Unplanned admossion due to valve failure; Acute renal injury with 3‐fold increment of serum cretinine level SECONDARY OUTCOME: Pressure Gradient; Aortic valve Area INCLUSION CRITERIA: 1) Patients to who TAVI is scheduled. Patient who has severe AS and symptomatic. AVA is 18‐28mm. Distance between annulus‐coronary artery>10mm. Creatinine level<2.0mg/dl, Expected life expenctency >1y, Indication for TAVI is decided by heart team. 2) Normal LDL and high LDL patients LDL level must be higher than 50mg/dl in 2 measurements. If less than 50mg/dl, 3rd measurement is allowed. Average LDL level must be higher than 50mg/dl.