Comparison of Nebulized and Intravenous Dexmedetomidine for Reducing Hemodynamic Response During Laryngoscopy and Endotracheal Intubation

INTERVENTION: Intervention1: Nil: Nil Intervention2: Dexmedetomidine: Nebulization,1mcg/kg,diluted with 5ml of 0.9% Normal saline, administered 15 minutes before induction Control Intervention1: Dexemedetomidine: Intravenous infusion 0.75mcg/kg , diluted 50 ml of 0.9% normal saline , infused over 15 minutes at the time of induction of general anaesthesia CONDITION: Health Condition 1: O‐ Medical and Surgical PRIMARY OUTCOME: Heart rate, SBP, DBP, MAPTimepoint: Baseline, 0 , 1 , 5 and 10 Minutes after intubation. SECONDARY OUTCOME: Propofol requirement during induction of general anaesthesia ; Total intraoperative fentanyl consumption ; Sedation score ; Adverse effects ,bradycardia,hypotension,sedation, othersTimepoint: During study drug administration, intraoperatively and in the recovery room. INCLUSION CRITERIA: ASA, physical status 1 or 2 , mallampatti grade 1 or 2, BMI less than 35 kilogram per metre square , elective surgery under general anaesthesia