Effect of rifampicin on theophylline pharmacokinetics in human beings.

Authors
Category Primary study
JournalThe Journal of the Association of Physicians of India
Year 1994
Theophylline pharmacokinetics before and after rifampicin administration was studied in 10 healthy volunteers. It was seen that Rifampicin significantly increased the volume of distribution of theophylline by 23.41% (p < 0.01) and its metabolic clearance by 47.65% (P < 0.05). This has got clinical significance in the treatment of patients of pulmonary tuberculosis with chronic obstructive airways disease where both the drugs may have to be given concurrently.
Epistemonikos ID: d401e8ff5534454802892770bb4580347ffe203d
First added on: Sep 11, 2023