Amoxicillin-clavulanate Versus Amoxicillin Versus Placebo in Acute Otitis Media in Children

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2026
The goal of this trial is to compare amoxicillin to amoxicillin-clavulanate and to placebo in the treatment of acute middle ear infections in small children. It will also learn about the possible side effects of antibiotics as compared to placebo. The main questions it aims to answer are: * Does treatment with antibiotics, either amoxicillin or amoxicillin-clavulanate, shorten the duration of symptoms in children with acute ear infection and what is the balance between pros and cons of antibiotics? Participants will: Take one of the two antibiotics or a placebo every day for 7 days.
Epistemonikos ID: d3f0521c34d39564946b80f8d68a75b6741046e6
First added on: Oct 17, 2026