Combined Scalp Acupuncture and Magnetic Stimulation for Gait Disorders in Parkinson's Disease

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Repetitive Transcranial Magnetic Stimulation (rTMS) plus Scalp Acupuncture Group:Stimulation will target the posterior putamen‐cortical network mapping point using rTMS, followed by scalp acupuncture administered within 30 minutes after each rTMS session. The treatment will be conducted once daily, five days per week, for a total of 10 sessions over two consecutive weeks.;Sham rTMS plus Acupuncture Group:Sham rTMS will be administered first, followed by scalp acupuncture within 30 minutes after each sham rTMS session. The treatment will be conducted once daily, five days per week, for a total of 10 sessions over two consecutive weeks.;rTMS plus Sham Acupuncture Group:The target will receive active repetitive transcranial magnetic stimulation (rTMS), followed by sham scalp acupuncture administered within 30 minutes after each rTMS session. This combined procedure will be performed once daily, five days per week, for a total of 10 sessions over two consecutive weeks.;Sham rTMS plus Sham Acupuncture Group:Sham rTMS will be administered first, followed by sham scalp acupuncture within 30 minutes after each sham rTMS session. This procedure will be conducted once daily, five days per week, for a total of 10 sessions over two consecutive weeks.;PD patient group:None;Healthy control group:None; CONDITION: Parkinson's disease PRIMARY OUTCOME: MDS‐UPDRS‐?; SECONDARY OUTCOME: Modified Hoehn and Yahr Staging Scale;Timed Up and Go Test;Freezing of Gait Questionnaire;Berg Balance Scale;Modified Ashworth Scale;Gait Analysis Parameters;Non‐Motor Symptoms Scale;Parkinson‘s Disease Sleep Scale;39‐Item Parkinson‘s Disease Questionnaire;Montreal Cognitive Assessment Basic;Hamilton Depression Rating Scale;Hamilton Anxiety Rating Scale;MRI Analysis Metrics;EEG Analysis Metrics; INCLUSION CRITERIA: This study consists of three parts. The inclusion criteria for each part are as follows: 1. Inclusion Criteria for Study Part 1: (1) Inclusion Criteria for PD Patients: 1) Meets the International Parkinson and Movement Disorder Society (MDS) Clinical Diagnostic Criteria for Parkinson's Disease (2015) and presents with postural and gait disturbance, defined as a score >=1 on Item 2.12 (Walking and Balance) and/or Item 2.13 (Freezing of Gait) of the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) Part II. 2) Aged between 45 and 80 years (inclusive), any gender, right‐handed. 3) Has been on stable anti‐parkinsonian medication for at least 3 months. 4) Hoehn and Yahr (H‐Y) stage 1 to 4, with disease duration <= 3 years. 5) Able to understand the study, agrees to participate, and provides written informed consent. (2) Inclusion Criteria for Healthy Controls: 1)Aged between 45 and 80 years (inclusive), any gender,
Epistemonikos ID: d3873c56695b6cbae54791380dc48d818df80768
First added on: Mar 07, 2026