A double-blind, randomised, placebo-controlled study to evaluate the effect of an orally-dosed herbal extract, Ageratum conyzoides, for the treatment of benign prostatic (BPH) symptoms in otherwise healthy males.

INTERVENTION: The investigational product is a tablet‐form herbal medicine, containing 250mg of Ageratum conyzoides extract. The daily dose will be 1 tablet per day (250mgtaken with the evening meal for 12 weeks. Compliance will be monitored through regular email and telephone communication between interviews (fortnightly) and the return of the bottles with remaining tablets at completion of the study. CONDITION: Benign Prostatic Hypertrophy PRIMARY OUTCOME: Day‐time and night time urinary frequency ‐ Assessed using a 1 week Patient Daily Diary. Symptoms of BPH ‐ Assessed by the IPSS (International Prostate Symptom Score) ; ; SECONDARY OUTCOME: Hormones ‐ Sex hormone binding globulin (SHBG) and Serum testosterone levels ‐ assessed by blood test Sleep quality ‐ Assessed by the Pittsburgh Sleep Questionnaire ; ; INCLUSION CRITERIA: Inclusion Criteria Male aged between 45‐80 Medically diagnosed with BPH Minimum score of 8 in the IPSS Written informed consent from the subject