Investigation of Methylene Blue for treatment of COVID-19 outpatients referred to pulmonary clinic

INTERVENTION: Intervention 1: Intervention group: In addition to the standard treatment, Covid‐19 outpatients are received orally methylene blue along with complementary materials two times per day in interval time 12 hours. The drug is used for 7 days until 14 days. Drug is prepared by Omid Rajabi pharmaceutical company. Methylene Blue (1 mg/Kg), Vitamin C, Glucose or sugar, Vitamine B1, B2, B3, Calcium Phosphate, Citrate Potassium, Carbonate Sodium, Glycine Amino Acid, Ginger, Lecithin, Ascorbyl Palmitate, Magnesium Stearate will be prepared as powder (in one sacchet) and it will used orally after dissolving in water. Intervention 2: Control group: Patients will received just the standard treatment. CONDITION: COVID‐19, COVID‐19. ; U07.1 PRIMARY OUTCOME: Chest pain. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Cough. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Diarrhea. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Fever. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Headache. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Oxygen pressure saturation. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Pulse oximeter. Respiratory Rate. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Shivery. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. Vomiting. Timepoint: Interval time: the third day, the sixth day, the eleventh day, the fourteenth day after using Methylene Blue. Method of measurement: Physical exam. SECONDARY OUTCOME: Hospital stay time. Timepoint: After 15 days. Method of measurement: Number of days. Mortality rate. Timepoint: After 30 days. Method of measurement: Review of medical records. INCLUSION CRITERIA: Outpatient COVID‐19 patients who confirmed by PCR or HRCT referred to pulmonary clinic SPO2 is between 70‐96 after taking off the mask