Pain control effectiveness of curcumin compare with ibuprofen after lower third molar removal surgery and A double blind randomized clinical trial

INTERVENTION: ‐ Step of intervention conclude Prepare medicine, Testing protocol to the surgeon, Recruit people, Surgical of Lower third molar impacted tooth, post‐operation instruction (People must note pain score (visual analog scale) after surgery 1(before first time taken drug), 2, 6 12, 24, 48, 72 hour and 7 days), People take drugs for control pain (note time of taken drug on papers), Follow‐ups after 7 days, People must keep paper and all retain drugs come back to the surgeon in Follow‐ups days ‐Drugs in the standard group consist of 1. Drug for control pain is Ibuprofen200mg(Same characteristic of drug capsules(blind random)) 2 Caps PO PC TID (18 caps)(Only packager knows keep secrete in the envelope)) 2. Amoxicillin 500mg 1 cap PO PC TID (20 caps) 3. Ultracet (Tramadol Paracetamol 37.5+325 mg) (1 tab) PO PC q8h (3 tabs) add when the first drugs are not enough to control pain People must note on paper when and how many to take drugs (Now: Researcher don't know Patient take Curcumin or ibuprofen),‐ Step of intervention conclude Prepare medicine, Testing protocol to the surgeon, Recruit people, Surgical of Lower third molar impacted tooth, post‐operation instruction (People must note pain score (visual analog scale) after surgery 1(before first time taken drug), 2, 6 12, 24, 48, 72 hour and 7 days), People take drugs for control pain (note time of taken drug on papers), Follow‐ups after 7 days, People must keep paper and all retain drugs come back to the surgeon in Follow‐ups days ‐Drugs in the standard group consist of 1. Drug for control pain is curcumin 250mg(Same characteristic of drug capsules(blind random)) 2 Caps PO PC TID (18 caps)(Only packager knows keep secrete in the envelope)) 2. Amoxicillin 500mg 1 cap PO PC TID (20 ca Experimental Drug,Experimental Drug Standard group,Experimental group CONDITION: Curcumin, Ibuprofen, Analgesic, impacted tooth, Post operative pain Patients who have indication surgical removal of lower third molar Impacted tooth (moderate point of pell and gregory classification) ; Curcumin, Ibuprofen, Analgesic, impacted tooth, Post operative pain PRIMARY OUTCOME: Pain score after surgical removal of lower third molar impacted tooth 1, 2, 6,12, 24,48,72 hour and 7 days visual analog scale (VAS) 1‐10 SECONDARY OUTCOME: N/A N/A N/A INCLUSION CRITERIA: 1. Patients aged between 18 to 29 years 2. Weight 40‐90 kgs 3. Clear indication for removal of lower third molars 3. Health patients with no uncontrolled systemic disease that is unsuitable to lower the third molar impacted 4. The moderate difficulty of lower third molar (Pederson difficulty inde X5‐6 score) 5. Operation time must be less or equal to 1 hour 6. An absence of periodontal disease, infection, swelling before surgery 7. Same person to surgery second time greater than or equal to 3 weeks