??Effect of Caffeine injection on pain after Cholecystectomy

INTERVENTION: Intervention 1: Intervention group: After entering the operating room, the patients undergo laparoscopic cholecystectomy under general anesthesia. After entering recovery, the experimental group was given caffeine injection drug by the anesthesiologist as an analgesic with a dose of 1 mg on a medicinal plant with medicinal characteristics: caffeine citrate 10 mg (3 ml) from Kimia drug company ‐ maximum 60 mg per dose. It is injected intravenously to reduce pain. The pain level of the patient is recorded 10, 30, and 60 minutes after the intervention by a trained doctor or nurse. After the necessary coordination with the surgeon and the recovery nurses, for pain intensity between 4 and 6, 0.25 mg/kg of Pethidine, and for intensity Pain between 7 and 10, 0.5 mg/kg of Pethidine is injected and recorded in the patient's file. Intervention 2: Control group: After entering the operating room, the patients undergo laparoscopic cholecystectomy under general anesthesia. After entering recovery, 3cc of normal saline is injected intravenously into the control group. The pain level of the patient is recorded 10, 30, and 60 minutes after the intervention by a trained doctor or nurse. After the necessary coordination with the surgeon and the recovery nurses, for pain intensity between 4 and 6, 0.25 mg/kg of pethidine, and for intensity Pain between 7 and 10, 0.5 mg/kg of pethidine is injected and recorded in the patient's file. CONDITION: Patients undergoing laparoscopic cholecystectomy. ; Cholelithiasis PRIMARY OUTCOME: Pain level after laparoscopic cholecystectomy. Timepoint: 10, 30 and 60 minutes after the operation. Method of measurement: Ruler‐like grading system (Visual Analog Scale) from 0 (no pain) to 10 (the most severe pain imaginable). The amount of Pethidine consumed. Timepoint: Until exiting recovery. Method of measurement: Record the amount of injected doses in the checklist. INCLUSION CRITERIA: Age range 15‐60 years Candidate for Cholecystectomy surgery Informed consent