Lyophilized Platelet-Rich Plasma Lysate vs Dextrose Prolotherapy for Partial Rotator Cuff Tears

The goal of this clinical trial is to learn whether lyophilized platelet‐rich plasma(PRP) lysate can improve shoulder symptoms, shoulder muscle strength, and tendon tearsize in adults with partial‐thickness rotator cuff tears, compared with hypertonicdextrose prolotherapy.The main questions this study aims to answer are: ‐ Does PRP lysate improve shoulder pain and function in people with partial‐thicknessrotator cuff tears? ‐ Does PRP lysate improve shoulder internal and external rotation strength? ‐ Does PRP lysate reduce the size of the rotator cuff tendon tear as measured byultrasound?Researchers will compare PRP lysate with hypertonic dextrose prolotherapy to determinewhether the changes in shoulder symptoms, muscle strength, and tendon tear size differbetween the two treatments.Participants will be randomly assigned to receive either PRP lysate or hypertonicdextrose. Each participant will receive one ultrasound‐guided injection into thepartially torn rotator cuff tendon each month for 3 months, for a total of threeinjections. Participants will complete a questionnaire about shoulder symptoms andfunction, undergo ultrasound examination of the rotator cuff, and have their shoulderrotation strength measured before the first injection and 1 month after the finalinjection. Participants assigned to the PRP lysate group will also have blood collectedfor preparation of the PRP lysate used for their treatment.