Can computed fractional flow reserve coronary ct angiography (FFRCT) offer an accurate noninvasive comparison to invasive coronary angiography (ICA)? 'the non-invasive cath.' a review

Purpose of study This abstract aims to review the accuracy of Computed Fractional Flow Reserve in the diagnosis of hemodynamically significant coronary artery stenosis and ruling out non-significant coronary artery stenosis when compared to FFR obtained during invasive coronary angiography. Methods used We conducted a Medline search using various combinations of 'Computed Fractional Flow Reserve,' 'Invasive coronary angiography' 'noninvasive,' 'significant stenosis' and 'coronary artery disease' to identify randomized trials published before October 1, 2019, for inclusion in this review. The following section reviews data from pivotal trials to determine a noninvasive strategy in appropriate patients to accurately detect functionally significant stenosis. Summary of results FFRCT is a novel noninvasive modality which localizes significant stenosis by means of crystal fluid dynamics eliminating the need for vasodilators. The specificity of FFRCT as analyzed by DISCOVER-FLOW, DeFACTO, NXT trials were 93%, 90%, and 86% respectively. Decrease in PCI was 5% in DISCORD trial and 61% in PLATFORM trial. The ADVANCE registry showed significantly lower events of CV death or MI with a negative FFRCT (>80) when compared with abnormal FFRCT. Furthermore, when FFRCT was studied as a first-line diagnostic modality in stable angina, it showed effectiveness in differentiating patients who require no invasive intervention in low risk (FFR >0.80) compared to high risk (FFR