Risk attitude and personality in people with multiple sclerosis facing the choice of different disease-modifying therapy scenarios.

Abstract Background As available disease-modifying therapies (DMTs) increase, evaluating benefit/risk presents greater difficulties, requiring people with MS (PwMS) to play crucial roles in choosing treatment. Although individual attitude toward risk may predict this evaluation, its relation to personality is little studied in MS literature. Objective To prospectively assess risk attitudes and personality traits of PwMS choosing a DMT. Methods In three Italian MS centers (2012–2015), 420 PwMS completed an ad hoc questionnaire on socio-demographic variables, personality, and standard-gamble questions, to evaluate MS- and DMT-related risks through two hypothetical drug scenarios. We assessed the influence of previously collected socio-demographic/clinical characteristics, and personality factors on risk attitude. Results Almost half of participants were mainly concerned about progressive multifocal leukoencephalopathy; Conclusions Both socio-demographic and personality factors affect risk attitude of PwMS facing different DMT scenarios. These findings could affect the shared decision-making process in selecting best treatment option for PwMS.