Post-parandial lipid effects of MK-0518 (raltegaravir) vs low-dose ritonavir (100mg daily) in HIV-negative adults

INTERVENTION: To compare the effects of oral dose ritonavir (RTV) 100mg daily for 28 days to oral dose raltegravir 400mg twice a day for 28 days. CONDITION: Human immunodeficiency virus (HIV) PRIMARY OUTCOME: To compared the effects of ritonavir (RTV) 100mg daily to those of raltegravir 400mg twice a day on postprandil triglyceride levels in healthy adults over four weeks. SECONDARY OUTCOME: Comparison of post‐prandial lipid effect of oral dose ritonavir 100mg daily and oral dose raltegravir 400mg twice a day. Measure menat of patient lipid laboratory bloods, radial artery tonometry ( measure the function of your arteries and done by placing a probe over the artery in your wrist for about 3o seconds) and Respirometry, (this test measures the speed of your metabolism, as well as the rate at which fats and sugars are metabolised in the body) INCLUSION CRITERIA: 1. adults taking a 'normal diet' with a stable weight and no desire to lose or gain weight body mass index between 20and 30kg/m2