Studies on relationship between epstein-barr virus (EBV) latent in fection and cervical squamous cell carcinoma

Objective To study the correlation of Epstein-Barr virus (EBV) Latent infection with the human cervical squamous cell carcinoma (CSCC).Methods Six cases of cervical intraepithelial neoplasia (CIN), 41 CSCC (22 from Shenzhen,19 from Wuhan )and 1 adenosquamous carcinoma were examined immunohistochemically for latent membrane protein 1(LMP1), Epstein-Barr viral nuclear antigen2(EBNA2) and ZEB replication activator protein (ZEBRA).36 CSCC(17 in Shenzhen women and 19 in Wuhan ) underwent EBERs test by RNA in situ hybridization assays. Results LMP1 positive rate was 22.2%(4/18)in CIN,6.3% in normal cervix and 54.8%(23/42) in all of CSCC cases,There were significant difference between three gropus.(P=0.00). The positive rates of EBERs in CSCC cases were 38.9% (14/36). The EBERs positive signals scattered in CSCC nuclei. Conclusions EBV Latent infection may contribute to pathogenesis of CSCC, but does not play a major role in the etiology of CSCC.