The Effect of oral consumption of Nigella Sativa in the treatment of autoimmune Hypothyroidism

INTERVENTION: Intervention 1: Nigella sativa group will receive 2 gram of Nigella sativa powder in the form of 1 gram packs with lunch and dinner meals for 8 weeks.The supplement will be given weekly and during the consumption possible side effects and keeping on consumption will be monitored. Intervention 2: Placebo group will receive 2 gram of starch in the form of 1‐gram packs with lunch and dinner meals weekly for 8 weeks and during the consumption possible side effects and keeping on consumption will be monitored. Nigella sativa group will receive 2 gram of Nigella sativa powder in the form of 1 gram packs with lunch and dinner meals for 8 weeks.The supplement will be given weekly and during the consumption possible side effects and keeping on consumption will be monitored Placebo Placebo group will receive 2 gram of starch in the form of 1‐gram packs with lunch and dinner meals weekly for 8 weeks and during the consumption possible side effects and keeping on consumption will be monitored Treatment ‐ Drugs CONDITION: Autoimmune thyroiditis Hashimoto’s Thyroiditis. ; Autoimmune thyroiditis PRIMARY OUTCOME: Added at 2017‐02‐12: Serum CAT. Timepoint: Added at 2017‐02‐12: At baseline and after 2 months of intervention. Method of measurement: Added at 2017‐02‐12: ELIZA. Added at 2017‐02‐12: Serum Concentrations of MDA, GPX, SOD and TAC. Timepoint: Added at 2017‐02‐12: Before and after intervention. Method of measurement: Added at 2017‐02‐12: ELIZA. Added at 2017‐02‐12: Serum GPX. Timepoint: Added at 2017‐02‐12: At baseline and after 2 months of intervention. Method of measurement: Added at 2017‐02‐12: ELIZA. Added at 2017‐02‐12: Serum SOD. Timepoint: Added at 2017‐02‐12: At baseline and after 2 months of intervention. Method of measurement: Added at 2017‐02‐12: ELISA. Added at 2017‐02‐12: Serum TAC. Timepoint: Added at 2017‐02‐12: At baseline and after 2 months of intervention. Method of measurement: Added at 2017‐02‐12: ELIZA. Serum concentration ofIL‐23. Timepoint: At baseline and after 2 months of intervention. Method of measurement: ELISA. Serum concentration ofT4, T3? TSH?TPOAb. Timepoint: At baseline and after 2 months of intervention. Method of measurement: ELISA. Serum concentration ofTGF‐ß. Timepoint: At baseline and after 2 months of intervention. Method of measurement: ELISA. SECONDARY OUTCOME: BMI. Timepoint: At baseline and after 2 months of intervention. Method of measurement: Weight divided by Height Square. Physical Activity. Timepoint: At baseline and after 2 months of intervention. Method of measurement: Physical Activity Questionare. Receiving Energy and Macronutrients. Timepoint: Before The first month termination and after the eight week. Method of measurement: 24‐hour memorial questionare. INCLUSION CRITERIA: INCLUSION CRITERIA: Age Range of 20‐50; Suffering from Hashimoto disease with the Diagnosis of Physician based on specialized Tests; Completing Informed Consent Form. Exclusion Criteria: not signed informed consent Form; physiologic Special conditions such as pregnancy and breast‐feeding; receiving supplements such as Vitamin E, C, Zinc, Folat, Cobalamin, Soy fitoestrogens in the last 3 month; suffering from any auotoimmune disease; history of thyroid operation, following any special diet