Behavior Change Wheel-Based Music Listening for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients

This is a single‐center, assessor‐blinded, parallel‐group randomized controlled trialdesigned to evaluate the effectiveness of a Behavior Change Wheel‐based music listeningintervention for chemotherapy‐related cognitive impairment in breast cancer patients.Eligible participants were adult female patients with histopathologically confirmedbreast cancer who received chemotherapy. A total of 90 participants were randomlyassigned in a 1:1 ratio to either the intervention group or the control group.Participants in the intervention group received routine nursing care plus a 12‐weekBCW‐based music listening intervention, which included relationship building, healtheducation, family involvement, individualized planning, self‐training, behavioralreinforcement, and regular feedback. Participants were instructed to listen toself‐selected music for at least 20 minutes per day. Participants in the control groupreceived routine nursing care, including health education, educational materials, onlinesupport, and regular follow‐up. The primary outcome was the change in FunctionalAssessment of Cancer Therapy‐Cognitive Function total score from baseline to Week 12.Secondary outcomes included FACT‐Cog subscale scores and PROMIS anxiety and depressionscores. Primary analyses followed the intention‐to‐treat principle, and analysis ofcovariance was used to compare post‐intervention outcomes between groups while adjustingfor baseline values. The study was approved by the Ethics Committee of The FirstAffiliated Hospital of Nanjing Medical University. Written informed consent was obtainedfrom all participants before enrollment. This study was registered retrospectively aftercompletion of participant enrollment and follow‐up.