Therapy of neurotic and pseudoneurotic symptoms with tofisopam

22 women of the age of 18-44 yr with neurasthenic and anxiety neuroses, and 30 women with AS pseudoneurasthenia of the age of 45-60 yr were cured for 4-10 weeks with tofisopam (daily doses 150-300 mg) and 14 days with placebo. The improvement after tofisopam is 67%, positive reaction on placebo is 46%. Greater difference was seen in the group with outstanding improvement and recovery, 59% after tofisopam, and 21% after placebo. With AS pseudoneurasthenia, more favourable curative effect of tofisopam was seen (77%, as against 33% on placebo). With younger women, these differences were less conclusive When we compare the symptoms of older women, the anxiety was less intensive with more somatoneurotical troubles and higher doses of an effective substance. With pseudoneurasthenia the placebo reaction was lower - 23%, as far as the research was started with placebo; with the administration of tofisopam in 61%. We did not succeed in proving the difference in the effect on vasomotoric or psychomuscular headache.