EFFECTS OF BETA 2 RECEPTOR BLOCKADE ON PULMONARY FUNCTION IN A HUMAN MODEL OF ACUTE HYDRIC OVERLOAD

INTERVENTION: Trade Name: CONGESCOR*100CPR RIV 2,5MG Pharmaceutical Form: Coated tablet INN or Proposed INN: BISOPROLOL FUMARATE CAS Number: 66722‐45‐0 Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 2.5‐ Trade Name: DILATREND*30CPR DIV 25MG Pharmaceutical Form: Tablet INN or Proposed INN: CARVEDILOL CAS Number: 72956‐09‐3 Concentration unit: mg milligram(s) Concentration type: equal Concentration number: 25‐ CONDITION: BETA BLOCKADE AND LUNG FUNCTION ; Therapeutic area: Body processes [G] ‐ Circulatory and Respiratory Physiological Phenomena [G09] PRIMARY OUTCOME: Main Objective: to avaluate the effects of beta 2 receptor blockade on pulmonary function in healthy subjects after water load Primary end point(s): absolute or percentage variations of DLCO Secondary Objective: none Timepoint(s) of evaluation of this end point: before and after 7 days of treatment SECONDARY OUTCOME: Secondary end point(s): none Timepoint(s) of evaluation of this end point: ‐ INCLUSION CRITERIA: healthy subjects aging between 30 and 60 yearsl Are the trial subjects under 18? no Number of subjects for this age range: 0 F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range 20 F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range