Study on the efficacy and mechanism of repetitive transcranial magnetic stimulation of the precuneus in the treatment of patients with amnestic mild cognitive impairment

INTERVENTION: real group:repetitive Transcranial Magnetic Stimulation;sham group:pseudo‐stimulus coil;healthy control group:None; CONDITION: amnestic mild cognitive impairment PRIMARY OUTCOME: the change in baseline compared to the total score of the Montreal Cognitive Assessment Scale (MoCA); SECONDARY OUTCOME: Auditory Verbal Learning Test (AVLT);Minimum Mental State Examination (MMSE);Symbol Digit Modalities Test (SDMT);Trail Making Test‐B (TMT‐B);Changes in brain functional connectivity;Changes in brain electrical activity frequency, power, distribution, and spatiotemporal dynamics of brain networks; INCLUSION CRITERIA: 1. aMCI group: (1) Age: 55 to 80 years old, gender not limited. (2) Right‐handed. (3) Have a junior high school education or above, possess certain reading and writing skills, and be capable of completing the content of this research. (4) Meet Petersen's diagnostic criteria: 1) Have a chief complaint of memory decline; 2) Disease course >3 months; 3) Scale assessment: Global Deterioration Scale (GDS) rating was 2 to 3, Clinical Dementia Scale(GDS) was 0.5 points, and the memory test score was 1.5 standard deviations in the age and education matched control group, MMSE >= 24 points, MOCA < 26 points, and the score of the Activities of Daily Living Scale (ADL‐20 items) is higher than 21 points; d.Memory impairment is the main symptom, while other cognitive domains remain relatively intact. (5) Geriatric Depression Scale (GDS) < 7. (6) Hachinski Ischemia Inde X(HIS) <= 4. (7) Medial temporal lobe atrophy Visual Scale (MTA‐scale) < 2 poin