The effect of rofecoxib on colorectal liver metastases

INTERVENTION: 1. Rofecoxib 25 mg/day 2. Placebo CONDITION: Colorectal cancer, liver metastases ; Cancer ; Malignant neoplasm of colon PRIMARY OUTCOME: Not provided at time of registration SECONDARY OUTCOME: Not provided at time of registration INCLUSION CRITERIA: 1. Age greater than or equal to 18 years 2. Either sex 3. Liver resection deemed clinically appropriate for management of metastatic Colorectal Cancer (CRC) liver disease 4. Duration between decision to perform liver resection and surgery greater than 2 weeks 5. Ability to give written informed consent 6. Telephone at home