Voltage laterality in the EEG of psychiatric patients.

In 2 EEG drug trials of a total of 75 chronic schizophrenic patients, certain voltage laterality shifts previously seen in an EEG chlorpromazine dose-range study were again observed. Comparisons of EEG voltage gains from each of the 2 hemispheres were made (at monthly intervals) for Ss receiving 12 wk. of treatment with chlorpromazine, haloperidol, clopenthixol, molindone, or a placebo. The laterality shifts seen in the previous study were consistent, the left side of the brain (dominant for speech) gaining voltage as a result of chlorpromazine or clopenthixol treatment (especially the former), or of clinical improvement, confirming the original published observations. The relatively infrequent registering of the phenomenon is attributed to methodological reasons. (PsycInfo Database Record (c) 2022 APA, all rights reserved)