The CHIPS trial: Control of Hypertension In Pregnancy Study

Primary research question:. For pregnant women with non-severe, non-proteinuric maternal hypertension at 14 - 33 weeks, will 'less tight' control (target diastolic blood pressure [dBP] of 100 mmHg) versus 'tight' control (target dBP of 85 mmHg) increase (or decrease) the likelihood of pregnancy loss or Neonatal Intensive Care Unit (NICU) admission for greater than 48 hours?. Secondary research question:. Will 'less tight' versus 'tight' control increase (or decrease) the likelihood of serious maternal complications?. Other research questions:. Will 'less tight' versus 'tight' control:. 1. Increase (or decrease) the likelihood of serious perinatal complications?. 2. Increase (or decrease) the likelihood of severe hypertension and pre-eclampsia?. 3. Increase (or decrease) the likelihood of maternal satisfaction with care?. 4. Result in significant changes in dBP or health care costs?. This is the resulting randomised trial from the pilot study registered under ISRCTN57277508.. As of 15/03/2010, this record has been updated to include a protocol amendment to the exclusion criteria, and the addition of the following countries to the countries of recruitment field: Colombia, Equatorial Guinea, Estonia, Poland, Qatar.. As of 03/06/2013, the following changes were made to the trial record:. 1. Hungary was added to the countries of recruitment and France, Malaysia and South Africa were removed.. 2. The anticipated end date was updated from 31/10/2013 to 31/03/2014. Please also note that recruitment for this trial is closed.. As of 21/10/2013, Equatorial Guinea and Qatar were removed from the countries of recruitment.