Randomised controlled trial of adjuvant promethazine for the relief of the pain of renal colic.

INTERVENTION: Randomised to adjuvant promethazine 25mg IV single dose or not, in addition to non‐steroidal anti‐inflammatory drug [NSAID] [indomethacin 100mg oral or per rectum [PR]] and morphine 2.5mg intravenous [IV], with additional 2.5mg increments at 10 minutely intervals as required. CONDITION: Renal colic PRIMARY OUTCOME: Difference in median visual analogue pain score [VAS score] for the degree of pain experienced at enrolment, 10, 20, 30 and 60 minutes post treatment SECONDARY OUTCOME: Proportion with >50% reduction in initial VAS for the degree of pain being experienced Proportion with VAS pain score <30mm at each time point Total dose of intravenous [IV] morphine required within 1st hour INCLUSION CRITERIA: Adults aged 18‐60 with clinical diagnosis of renal colic, confirmed by computed tomography scan within 48 hours of presentation