PRF + Minocycline vs Arestin in Non-surgical Perio Therapy

Periodontitis is a chronic, biofilm‐modulated inflammatory disease characterized bymicrobial dysbiosis and a dysregulated host immune response, eventually resulting in thegradual breakdown of the periodontal attachment apparatus. While non‐surgical periodontaltherapy (NSPT) remains the first choice of treatment, its capability to completelyresolve inflammation and pocketing in moderate disease severity may be limited,supporting the use of adjunctive antimicrobial or biologic interventions. Platelet‐richfibrin (PRF) and locally administered antibiotics, including minocycline, haveindividually shown clinical advantages; nonetheless, evidence assessing their combinedutility remains unexplored. This split‐mouth randomized controlled clinical trial (RCT)aims to compare the clinical efficacy of PRF combined with minocycline versus minocyclinemicrospheres hydrochloride (Arestin) as adjuncts to NSPT in patients with Stage II orIII, Grade A or B periodontitis.