Efficacy of indomethacin in in-vitro fertilisation treatment in the modified natural cycle

INTERVENTION: Use of indomethacin (Indocid®) 50 mg versus placebo during IVF‐treatment in the modified natural cycle. Dosage scheme: three times a day, starting on the day of ovulation triggering and ending on the morning of the follicle aspiration (total of seven capsules per cycle). CONDITION: In‐vitro fertilisation‐treatment in the modified natural cycle, IVF in the natural cycle ; Pregnancy and Childbirth ; In‐vitro fertilisation‐treatment PRIMARY OUTCOME: Number/percentage of patients per study group that have one or more ovulations prior to follicle aspiration. SECONDARY OUTCOME: Number/percentage of patients per study group that achieve an on‐going pregnancy (defined as an intact intra‐uterine pregnancy at 12 weeks gestation) INCLUSION CRITERIA: 1. Indication for IVF or Intracytoplasmic Sperm Injection (ICSI) treatment 2. Age 18 up to 37 years 3. Ovulatory cycle of 26 to 35 days