Efficacy and Safety of Tranexamic acid+Pericervical Tourniquet, Rectal Misoprostol+Pericervical Tourniquet, and Pericervical Tourniquet alone on Blood Loss at open Myomectomy

INTERVENTION: Misoprostol Peri cervical catheter Tranexamic acid CONDITION: PRIMARY OUTCOME: Primary efficacy outcome: estimated intraoperative blood loss and Primary safety outcome: frequency of vomiting. SECONDARY OUTCOME: Secondary efficacy outcomes: need for blood transfusion, change in haemoglobin concentration, prolonged hospital stay and Secondary safety outcomes: diarrhoea, headaches, chills, fever. INCLUSION CRITERIA: INCLUSION CRITERIA 1. Uterine size =12 weeks of gestation 2. No previous myomectomy or pelvic surgery 3. Willing to provide informed consent