Comparison of the efficacy of oral non-steroidal anti-inflammatory drugs versus opioid painkillers after external dissection and internal ligation of mixed hemorrhoids: an open-label randomized controlled study

INTERVENTION: Loratropine Sodium Group:Patients in the losofen sodium group received oral administration of losofen sodium tablets (60 mg every 8 hours as needed) for pain relief.;Amphetamine hydrocodone group:Patients in the amfeprofen oxycodone group received oral administration of amfeprofen oxycodone tablets (5mg / 6 hours as needed) for pain relief.; CONDITION: Postoperative pain after hemorrhoidectomy PRIMARY OUTCOME: The average VAS pain score of the subjects within 4 weeks after the operation;The average VAS pain score of the subjects within two weeks after the operation; SECONDARY OUTCOME: Actual dosage and frequency of the medication;The average VAS pain score 1 week after the operation;The HDSS score at the 4th week after the operation;The average VAS pain score 24 hours after the operation;The score of the European Five‐Dimensional Health Quality of Life Scale (EQ‐5D‐3L) at the 4th week after the operation;Satisfaction level;The HDSS score at the 2nd week after the operation;The score of the European Five‐Dimensional Health Quality of Life Scale (EQ‐5D‐3L) at the 12th week after the operation;The average VAS pain score 8 hours after the operation;The average VAS pain score 36 hours after the operation;The score of the European Five‐Dimensional Health Quality of Life Scale (EQ‐5D‐3L) at the 2nd week after the operation;The HDSS score at the 12th week after the operation;Recurrent rate; INCLUSION CRITERIA: 1. Age >=18 years old; 2. Patients diagnosed with severe circular mixed hemorrhoids according to the Chinese Guidelines for the Diagnosis and Treatment of Hemorrhoids (2020) and who underwent external dissection and internal ligation of mixed hemorrhoids during hospitalization; 3. Voluntarily sign the informed consent form and follow the requirements of the protocol;