Frequency of multi-drug resistance and mutations in Mycobacterium A tuberculosis isolates from Punjab state of India

Commonest known mutation for RIF in rpoB gene and INH in kat G gene was S531L [80/ 137; 58.4%] and S315T1 [119/134; 88.8%] respectively. Mutations in inhA were found in 21/134 ]15.7%] strains. Average turn-around time [TAT] for dispatch of result toPunjab was 4.6 days. Prevalence of RIF resistance in Punjab was found to be 22.6%. Common mutations for RIF and INH were similar to that in other regions of country. GenoType MTBDRplus was found to be useful assay for rapid detection of MDR-TB, responsible for determining better management of MDR-TB patients under the programme